Medical Cannabis Studies

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Action of Cannabidiol on the Anxiety and Other Effects Produced by D9-THC in Normal Subjects (1982)

It was verified that cannabidiol blocks anxiety caused by D9-tetrahydrocannabinol, in addition to blocking other effects similar to those of marijuana. The results of this study suggest that the effects of cannabidiol, unlike the effects of D9-tetrahydrocannabinol, could be involved in the antagonism of the effects between the two cannabinoids. View study
Activation of the Cannabinoid Type-1 Receptor Mediates the Anticonvulsant Properties of Cannabinoids in the Hippocampal Neuronal Culture Models of Acquired Epilepsy and Status Epilepticus (2006)

Cannabinoids have anticonvulsant properties, but their effects have not been evaluated in hippocampal neuronal culture models of acquired epilepsy (AD) and status epilepticus (SE). The results of this study represent powerful tools to investigate the molecular mechanisms that mediate the effects of cannabinoids on neuronal excitability. View study
Activation of Type 1 Cannabinoid Receptor (CB1R) Promotes Neurogenesis in Murine Subventricular Zone Cell Cultures (2013)

These results demonstrate that the activation of the endocannabinoid receptor CB1R induces the proliferation, self-renewal and neuronal differentiation of the cell cultures of the neonatal subventricular zone in animal models. View study
Activity of cannabis in relation to its delta'-trans-tetrahydro-cannabinol content (1981)

Tetrahydrocannabinol (THC) can represent about one third of the activity of the herb or cannabis resin. In this study it has been shown that some fractions of the crude drug show an inhibitory effect, while others have a THC enhancing effect, which can have an important influence on the types of cannabis preparation used. View study
Activity of muscarinic, galanin and cannabinoid receptors in the prodromal and advanced stages in the triple transgenic mice model of Alzheimer's disease (2016)

The positive regulation of the galaninnergic and endocannabinoid systems supports the hypothesis of their neuroprotective functions, which are established before clear clinical cognitive symptoms of Alzheimer’s disease appear. View study
Acute administration of cannabidiol in vivo suppresses ischaemia-induced cardiac arrhythmias and reduces infarct size when given at reperfusion (2010)

This is the first study to demonstrate an antiarrhythmic effect of cannabidiol (CBD) after myocardial ischemia and reperfusion (I / R), and it is also the first to demonstrate that acute administration of a single dose of CBD is sufficient to reduce myocardial tissue injury, regardless of whether it is administered before or after coronary occlusion. Although more detailed studies are required to elucidate the mechanism by which CBD conserves tissue in I / R, this data extends to the currently very limited literature that details the role of CBD in the cardiovascular system and firmly establishes its potential as an cardioprotective agent. View study
Adolescent Exposure to Chronic Delta-9-Tetrahydrocannabinol Blocks Opiate Dependence in Maternally Deprived Rats (2009)

THC acts as a homeostatic modifier that worsens the reward effects of morphine in naive animal models, but which would improve deficits in maternal models. This suggests the use of cannabis individuals subjected to an adverse postnatal environment. View study
Agonistic Properties of Cannabidiol at 5-HT1a Receptors (2005)

This study demonstrates that cannabidiol (CBD) is a modest agonist at the human 5-HT1a receptor. However, additional work and studies are needed to compare the potential of CBD with other serotonin receptors and other species. The results indicate that CBD is potentially useful beyond the domain of cannabinoid receptors. View study
Allosteric Modulation of the Cannabinoid CB1 Receptor (2005)

We investigated the pharmacology of three new compounds, Org 27569, Org 27759, and Org 29647 in the CB1 cannabinoid receptor. In the equilibrium binding assays, the Org compounds significantly increased the binding of a CB1 receptor agonist, indicative of an allosteric effect of positive cooperation. The data presented demonstrate for the first time, that the cannabinoid receptor CB1 contains an allosteric binding site that can be recognized by synthetic small molecule ligands. View study
Alterations in the endocannabinoid system in the rat valproic acid model of autism (2013)

Prenatal exposure to valproic acid is associated with alterations in the endocannabinoid system of the brain. These results indicate that it is possible that endocannabinoid dysfunction may be the basis of behavioral abnormalities observed in autism spectrum disorders. View study
Altered striatal reward processing in abstinent dependent cannabis users: Social context matters. (2019)

The public perception of cannabis as relatively harmless, together with the declared medical benefits, has led to progress towards its legalization. The present study aimed to investigate whether cannabis dependence is associated with lasting alterations in behavioral and neural responses to social reward in 23 abstinent cannabis-dependent men and 24 matched non-using controls. View study
American Medical Society for Sports Medicine position statement: concussion in sport. (2013)

Concussion is defined as a transient alteration of traumatically induced brain function and involves a complex pathophysiological process. The purpose of this article was to provide a summary of best practices based on evidence to help physicians with the evaluation and management of sports concussion. View study