Antitumor Activity of Plant Cannabinoids with Emphasis on the Effect of Cannabidiol on Human Breast Carcinoma. (2006).
Author(s): Alessia Ligresti, Aniello Schiano Moriello, Katarzyna Starowicz, Isabel Matias, Simona Pisanti, Luciano De Petrocellis, Chiara Laezza, Giuseppe Portella, Maurizio Bifulco, and Vincenzo Di Marzo. A comparison of antitumor properties of different cannabinoids. The results obtained show that cannabidiol is the most potent inhibitor of the growth of cancer cells. View study
A pilot clinical study of Δ9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme. (2006).
Author(s): M. Guzmán, M.J. Duarte , C. Blázquez , J. Ravina, M.C. Rosa, I. Galve-Roperh , C. Sánchez , G. Velasco and L. González-Feria. Due to its ability to inhibit tumor growth in animals, THC and other cannabinoids have been suggested as antitumor drugs. This is the first clinical study to test the application of THC in human patients with recurrent glioblastoma multiforme. The results demonstrate the safety profile of THC and its action on tumor cells, which establishes the basis for future trials. View study
Cannabidiol (CBD) Priming Enhances Cisplatin Killing Of Cancer Cells. (No year).
Author(s): Aine B Henley, Alistair V Nunn, Gary S Frost, Jimmy D Bell. CBD possesses properties that, through “priming”, make it a potentially important adjunct to standard chemotherapy. Pre-treating tumour cells with a “priming agent” prior to the chemotherapeutic agent can enhance the efficacy of standard therapies. View study
Cannabidiol Enhances the Inhibitory Effects of Δ9-Tetrahydrocannabinol on Human Glioblastoma Cell Proliferation and Survival. (2012).
Author(s): Jahan P. Marcu1 , Rigel T. Christian1 , Darryl Lau1 , Anne J. Zielinski1 , Maxx P. Horowitz1 , Jasmine Lee1 , Arash Pakdel1 , Juanita Allison1 , Chandani Limbad1 , Dan H. Moore1,2, Garret L. Yount1 , Pierre-Yves Desprez1 , and Sean D. McAllister1. Adding cannabidiol to Δ9-THC may improve the effectiveness of Δ9-THC in the treatment of glioblastoma in patients with cancer. When treating the cells with both compounds it was observed that these acted synergistically to inhibit cell proliferation. View study
Anandamide Induces Apoptosis in Human Cells via Vanilloid Receptors. (2000).
Author(s): Ana Juknat, Ewa Kozela, Nathali Kaushansky, Raphael Mechoulam and Zvi Vogel. The results of this study indicate that cannabinoid receptors have a protective role against apoptosis induced by endocannabinoid anandamide (AEA) through vanilloid receptors. View study
Author(s): Paola Massi, Marta Solinas, Valentina Cinquina and Daniela Parolaro. There is emerging evidence to suggest that cannabidiol (CBD) is a potent inhibitor of cancer growth and spread. Its effectiveness is linked to its ability to target multiple cellular pathways that control tumorigenesis through the modulation of different intracellular signals depending on the type of cancer considered. View study
Cannabinoids and cancer: pros and cons of an antitumour strategy. (2006).
Author(s): Maurizio Bifulco, 2 Chiara Laezza, 1 Simona Pisanti & 1 Patrizia Gazzerro. Cannabinoids have the ability to selectively affect tumor cells more than their untransformed counterparts that may even be protected from cell death. These findings suggest that the cannabinoid system represents a promising target for cancer treatment. View study
Cannabinoids and ceramide: Two lipids acting hand-by-hand. (2005).
Author(s): Guillermo Velasco, Ismael Galve-Roperh, Cristina Sa´nchez, Cristina Bla´zquez, Amador Haro, Manuel Guzma´nT. This study suggests that endocannabinoids constitute a new family of lipid signaling cues responsible for the regulation of the development and survival of neuronal cells, and provide a conceptual and mechanical basis for the effects of cannabinoids derived from marijuana. These findings provide a new conceptual view of how cannabinoids act and pose interesting physiological and therapeutic questions. However, more research is needed to determine the real impact of cannabinoids on brain development and the possible participation of ceramide in these events. View study
Cannabinoids as therapeutic agents in cancer: current status and future implications. (2014).
Author(s): Bandana Chakravarti, Janani Ravi and Ramesh K. Ganju. Cannabinoids derived from different sources can regulate different signaling pathways, modulate different types of tumor cells and the physiological system of the host. View study
Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes. (2006).
Author(s): Arkaitz Carracedo, Meritxell Gironella, Mar Lorente, Stephane Garcia, Manuel Guzmán, Guillermo Velasco, and Juan L. Iovanna. Cannabinoids have the property of causing the death of pancreatic tumor cells through a CB2 receptor. This and other findings in this study can help establish the basis for a new type of therapy for pancreatic cancer. View study
Author(s): Manuel Guzmán. Cannabinoids have properties with positive effects in the treatment against cancer. They inhibit nausea and vomiting caused by chemotherapy while stimulating appetite and reducing pain. It has also been shown to inhibit tumor growth in laboratory animals. These findings can lay the foundation for future trials aimed at evaluating the possible anti-volume activity of cannabinoids in humans. View study
Cannabinoids Protect Astrocytes from Ceramide-induced Apoptosis through the Phosphatidylinositol 3-Kinase/Protein Kinase B Pathway. (2002).
Author(s): Teresa Gómez del Pulgar, María L. de Ceballos, Manuel Guzmán, and Guillermo Velasco. Cannabinoids protect astrocytes from cell death induced by ceramide, which is an important evidence of the “astrofringent” role of cannabinoids. View study
CBD inhibits angiogenesis by multiple mechanisms. (2012).
Author(s): M Solinas, P Massi, AR Cantelmo, MG Cattaneo, R Cammarota, D Bartolini, V Cinquina, M Valenti, LM Vicentini, DM Noonan, A Albini and D Parolaro. Cannabidiol can inhibit angiogenesis (a physiological process that consists in the formation of new blood vessels from pre-existing vessels) through different mechanisms. Based on the results of this study, it is demonstrated that cannabidiol has the potential to be used as an effective agent in cancer therapy. View study
Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro. (2007).
Author(s): A Thomas, GL Baillie, AM Phillips, RK Razdan, RA Ross and RG Pertwee. It has been shown that Cannabidiol, a non-psychoactive component of cannabis, has low affinity for cannabinoid receptors CB1 and CB2, and in this study the first evidence is shown that it can also show the inverse agonism of the CB2 receptor. What can contribute to its documented anti-inflammatory properties. View study
Medications for the treatment of cannabis dependence. (2014).
Author(s): Kushani Marshall, Linda Gowing, Robert Ali, Bernard Le Foll. Effectiveness and safety of pharmacotherapies in the treatment of cannabis use disorders and the reduction of withdrawal symptoms. View study
Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy. (2010).
Author(s): Mohanraj Rajesh, Partha Mukhopadhyay,SÁndor BÁtkai, Vivek Patel, Keita Saito, Shingo Matsumoto, Yoshihiro Kashiwaya, Béla Horváth, Bani Mukhopadhyay, Lauren Becker, György Haskó, Lucas Liaudet, David A. Wink, Aristidis Veves, Raphael Mechoulam. Pál Pacher. Studies that suggest that CBD has great therapeutic potential in the treatment of diabetes and other cardiovascular disorders. View study
Is the cardiovascular system a therapeutic target for cannabidiol? (2012).
Author(s): Christopher P. Stanley, William H. Hind & Saoirse E. O’Sullivan. Cannabidiol, in addition to its beneficial effects in many disorders, can also be important for the treatment of cardiovascular diseases, since it acts directly on the isolated arteries and causes vasorelaxation. View study
Cannabis Alleviates Symptoms Of Crohn’s Disease. (2005).
Author(s): Jeff Hergenrather. A pilot study conducted in patients with Crohn’s disease, who underwent treatment with cannabis, reported numerous benefits, such as reduction of: vomiting, depression, nausea, pain and fatigue; as well as an improvement in appetite and activity. View study
Cannabis Finds Its Way into Treatment of Crohn’s Disease. (2013).
Author(s): Rudolf Schicho, Martin Storr. For a long time in traditional medicine, cannabis has been used for the treatment of intestinal diseases. This article shows that the cannabis sativa is highly efficient and has a great therapeutic potential to alleviate the inflammations and affections of this disease. View study
A pilot clinical study of Δ9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme. (2006).
Author(s): M. Guzmán, M.J. Duarte, C. Blázquez, J. Ravina, M.C. Rosa, I. Galve-Roperh, C. Sánchez, G. Velasco and L. González-Feria. Due to its ability to inhibit tumor growth in animals, THC and other cannabinoids have been suggested as antitumor drugs. This is the first clinical study to test the application of THC in human patients with recurrent glioblastoma multiforme. The results demonstrate the safety profile of THC and its action on tumor cells, which establishes the basis for future trials. View study
Adolescent Exposure to Chronic Delta-9-Tetrahydrocannabinol Blocks Opiate Dependence in Maternally Deprived Rats. (2009).
Author(s): Lydie J Morel, Bruno Giros, and Vale´rie Dauge´,. THC acts as a homeostatic modifier that worsens the reward effects of morphine in naive animal models, but which would improve deficits in maternal models. This suggests the use of cannabis individuals subjected to an adverse postnatal environment. View study
Cannabidiol Enhances the Inhibitory Effects of Δ9-Tetrahydrocannabinol on Human Glioblastoma Cell Proliferation and Survival. (2010).
Author(s): Jahan P. Marcu, Rigel T. Christian, Darryl Lau, Anne J. Zielinski, Maxx P. Horowitz, Jasmine Lee, Arash Pakdel, Juanita Allison, Chandani Limbad, Dan H. Moore, Garret L. Yount, Pierre-Yves Desprez, and Sean D. McAllister. Adding cannabidiol to Δ9-THC may improve the effectiveness of Δ9-THC in the treatment of glioblastoma in patients with cancer. When treating the cells with both compounds it was observed that these acted synergistically to inhibit cell proliferation. View study
Antidepressant-Like and Anxiolytic-Like Effects of Cannabidiol: A Chemical Compound of Cannabis sativa. (2014).
Author(s): Alexandre R. de Mello Schier, Natalia P. de Oliveira Ribeiro, Danielle S. Coutinho, Sergio Machado, Oscar Arias-Carrión, José A. Crippa, Antonio W. Zuardi, Antonio E. Nardi and Adriana C. Silva. Cannabidiol (CBD) is a non-psychotomimetic component of Cannabis sativa with great psychiatric potential, which includes its use as an antidepressant and anxiolytic compound. Studies with animal models, which perform a myriad of experiments, suggest that CBD exhibited anxiety and antidepressant effects. View study
Cannabidiol Arrests Onset of Autoimmune Diabetes in NOD Mice. (2008).
Author(s): Lola Weiss1,* , Michael Zeira1, Shoshana Reich1, Shimon Slavin1, Itamar Raz2, Raphael Mechoulam3, and Ruth Gallily. This study states that cannabidiol, which is known to be safe for man, could potentially be used as a therapeutic agent for the treatment of type 1 diabetes. View study