Medical Cannabis Studies

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Cannabidiol displays antiepileptiform and antiseizure properties in vitro and in vivo (2009)

It is demonstrated that phytocannabinoids have important therapeutic properties, and specifically cannabidiol or CBD has anticonvulsant properties in animal models which highlights its potential as a new antiepileptic drug. View study
Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro (2007)

It has been shown that Cannabidiol, a non-psychoactive component of cannabis, has low affinity for cannabinoid receptors CB1 and CB2, and in this study the first evidence is shown that it can also show the inverse agonism of the CB2 receptor. What can contribute to its documented anti-inflammatory properties. View study
Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia (2012)

CBD is a component of cannabis that moderately inhibits the degradation of endocannabinoid anandamide. These results indicate that the inhibition of the deactivation of anandamide contributes to the antipsychotic effects of CBD, which could suggest a novel mechanism in the treatment of schizophrenia. View study
Cannabidiol Enhances the Inhibitory Effects of ?9-Tetrahydrocannabinol on Human Glioblastoma Cell Proliferation and Survival (2010)

Adding cannabidiol to ?9-THC may improve the effectiveness of ?9-THC in the treatment of glioblastoma in patients with cancer. When treating the cells with both compounds it was observed that these acted synergistically to inhibit cell proliferation. View study
Cannabidiol exerts anti-convulsant effects in animal models of temporal lobe and partial seizures (2012)

In this study, cannabidiol is evidenced as a strong candidate to treat human epilepsies, since it reduces the severity of seizures. View study
Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes (2014)

A study that demonstrates the potential of CBD as a promising therapeutic agent for the treatment of acne vulgaris, due to its anti-inflammatory, lipostatic and antiproliferative effects. View study
Cannabidiol for the treatment of psychosis in Parkinson's disease (2008)

One of the biggest challenges faced by doctors against Parkinson’s disease is the treatment of psychosis, which is why the treatment with CBD has been suggested due to its antipsychotic and neuroprotective effects. In this study, its efficacy was evaluated and demonstrated. View study
Cannabidiol improves brain and liver function in a fulminant hepatic failure-induced model of hepatic encephalopathy in mice (2010)

The present study suggests that cannabidiol restores liver function, normalizes levels of 5-hydroxytryptamine (5-HT) and improves brain pathology according to the normalization of brain function. Therefore, the effects of cannabidiol can result from a combination of its actions in the liver and brain. View study
Cannabidiol in Anxiety and Sleep: A Large Case Series. (2019)

The objective of the present study was to determine if cannabidiol (CBD) helps to improve sleep and / or anxiety in a clinical population. It was concluded that cannabidiol may be beneficial for anxiety-related disorders. Controlled clinical studies are needed. View study
Cannabidiol in patients with seizures associated with Lennox-Gastaut syndrome (GWPCARE4): a randomised, double-blind, placebo-controlled phase 3 trial (2018)

The Lennox-Gastaut syndrome is a severe form of epileptic encephalopathy resistant to conventional treatments. It has been shown that cannabidiol is effective for the treatment of patients with gout attacks associated with Lennox-Gastaut syndrome and is generally well tolerated. View study
Cannabidiol Inhibits Cancer Cell Invasion Via Upregulation Of Tissue Inhibitor Of Matrix Metalloproteinases-1 (2011)

Based on the results of this study, there is evidence to suggest that cannabidiol (CBD) could be used for the treatment of highly invasive cancers. View study
Cannabidiol Inhibits Growth and Induces Programmed Cell Death in Kaposi Sarcoma�Associated Herpesvirus Infected Endothelium (2012)

Cannabidiol has properties that inhibit the expression of the herpesvirus receptor associated with Kaposi’s sarcoma, which leads to taking cannabidiol under clinical consideration for the treatment of Kaposi’s sarcoma. View study