Medical Cannabis Studies

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Cannabidiol inhibits human glioma cell migration through a cannabinoid receptor-independent mechanism (2005)

The results of this investigation reinforced the evidence of the antitumor properties of cannabidiol (CBD) and also demonstrated its ability to limit tumor invasion. View study
Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1 (2012)

Cannabinoids have the property of inhibiting the invasion of cancer cells by inducing the intercellular adhesion molecule-1 (ICAM-1), which in turn confers the induction of the tissue inhibitor of matrix metallo-proteinases-1 (TIMP-1). View study
Cannabidiol inhibits pathogenic T cells, decreases spinal microglial activation and ameliorates multiple sclerosis-like disease in C57BL/6 mice (2011)

The cannabidiol (CBD) is, potentially, a safe and effective alternative for alleviating neuroinflammation and neurodegeneration. CBD ameliorates clinical signs of experimental autoimmune encephalomyelitis in mice, immunized against myelin oligodendrocyte glycoprotein. Suppression of microglial activity and T�cell proliferation by CBD appeared to contribute to these beneficial effects. View study
Cannabidiol is a negative allosteric modulator of the type 1 cannabinoid receptor (no year)

This study was made based on the hypothesis that cannabidiol can inhibit the activity of cannabinoid agonists through the negative allosteric modulation of CB1. The results of this study showed that cannabidiol behaved as a non-competitive allosteric modulator of CB1.The allosteric modulation, together with the effects that are not CB1, can show the in vivo effects of cannabidiol. The allosteric modulators of CB1 have the potential to treat the central nervous system and peripheral disorders, while avoiding the adverse effects associated with orthosteric agonism or CB1 antagonism. View study
Cannabidiol is a Potent Inhibitor of the Catalytic Activity of Cytochrome P450 2C19 (2012)

Through this research the inhibitory effect of cannabidiol (CBD) on the catalytic activity of cytochrome P450 2C19 (CYP2C19) was studied. In this study it was demonstrated that CBD caused a potent inhibition of CYP2C19, in which a phenolic hydroxyl group Free and the pentyl side chain of the CBD can perform important functions. View study
Cannabidiol is an allosteric modulator at mu- and delta-opioid receptors (2006)

This review seeks to verify if cannabidiol is an allosteric modulator in mu and delta opioid receptors. This study showed that cannabidiol is an allosteric modulator in mu and delta opioid receptors. This property is shared by THC but not by rimonabant.10 ?M View study
Cannabidiol Post-Treatment Alleviates Rat Epileptic-Related Behaviors and Activates Hippocampal Cell Autophagy Pathway Along with Antioxidant Defense in Chronic Phase of Pilocarpine-Induced Seizure (2016)

In the chronic phase of epilepsy, post-treatment with cannabidiol could be considered as a protection mechanism of the temporal lobe, which improves the induction of the cellular autophagy pathway and antioxidant defense. View study
Cannabidiol Protects against Doxorubicin-Induced Cardiomyopathy by Modulating Mitochondrial Function and Biogenesis (2014)

This research was based on studying the effects of cannabidiol (CBD) in a well-established mouse model of cardiotoxicity-induced cardiomyopathy (DOX). View study
Cannabidiol protects liver from binge alcohol-induced steatosis by mechanisms including inhibition of oxidative stress and increase in autophagy (2014)

Cannabidiol prevents acute hepatic steatosis induced by alcohol in mice. The effective prevention of hepatic steatosis avoids the progressive damage caused by alcohol in the liver. View study
Cannabidiol provides long-lasting protection against the deleterious effects of inflammation in a viral model of multiple sclerosis: A role for A2A receptors (2013)

This study results highlight the anti-inflammatory effects of cannabidiol in this viral model of multiple sclerosis and demonstrate the significant therapeutic potential of this compound for the treatment of pathologies with an inflammatory component. View study
Cannabidiol Reduces A?-Induced Neuroinflammation and Promotes Hippocampal Neurogenesis through PPAR? Involvement (2011)

Based on the research carried out on rats in this study, it was possible to observe in the results that blocking the peroxisome proliferator-activated receptor-c (PPARc), could significantly reduce the effects of CBD on reactive gliosis and on damage neuronal Also due to its interaction in PPARc, it was observed that CBD stimulates hippocampal neurogenesis. View study
Cannabidiol reduces host immune response and prevents cognitive impairments in Wistar rats submitted to pneumococcal meningitis (2012)

The descriptive results showed that the prolonged treatment with 10 mg / kg of cannabidiol administered to Wistar rats prevented the deterioration of memory in rats with pneumococcal meningitis. Also, it was confirmed that cannabidiol has anti-inflammatory effects in pneumococcal meningitis and prevents cognitive sequelae. View study