Medical Cannabis Studies

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D9-Tetrahydrocannabinol inhibits epithelial growth factor-induced lung cancer cell migration in vitro as well as its growth and metastasis in vivo (2008)

It has been shown that THC (marijuana’s main cannabinoid) potentiates or inhibits tumor growth, depending on the type of cancer and its pathogenesis. These data suggest that THC and other cannabinoids should be explored as new therapeutic molecules for the treatment of certain lung cancers. View study
D9-Tetrahydrocannabinol-Induced Apoptosis in the Thymus and Spleen as a Mechanism of Immunosuppression in Vitro and in Vivo (2002)

Through this study, we hypothesized that exposure to 9 �Tetrahydrocannabinol (THC) leads to the induction of apoptosis in lymphocyte populations. The results suggest that in vivo exposure to THC can lead to a significant suppresion of the immune response by induction of apoptosis. View study
Deficient Social and Play Behavior in Juvenile and Adult Rats after Neonatal Cortical Lesion: Effects of Chronic Pubertal Cannabinoid Treatment (2004)

The medial prefrontal cortex (mPFC) contributes to the development of social behavior skills of adults, social motivation and personal hygiene. In addition, the results of this study suggest that the cannabinoid system has participation in anxiety and social behavior. View study
Delta 9-tetrahydrocannabinol inhibits cell cycle progression by downregulation of E2F1 in human glioblastoma multiforme cells (2008)

This research used several experimental approaches, which identified delta-9-tetrahydrocannabinol (D9 -THC) as an essential mediator of the anticancer action of the cannabinoid. Throughout the study it was demonstrated that D9 -THC considerably affects the viability of the cells of glioblastoma multiforme (GBM) through a mechanism that seems to cause the arrest of G1 due to the negative regulation of E2F1 and Cyclin A. View study
Delta-9-tetrahydrocannabinol for nighttime agitation in severe dementia (2006)

Dronabinol reduces nocturnal motor activity and agitation in patients with severe dementia. Thus, it represents a great potential for the safe treatment of alterations in dementia. View study
Design, Synthesis, Biological Properties, and Molecular Modeling Investigations of Novel Tacrine Derivatives with a Combination of Acetylcholinesterase Inhibition and Cannabinoid CB1 Receptor Antagonism (2009)

Through this study it was possible to discover new hybrid molecules 12, 13, 20, 21 that exhibit inhibitory activities of AChE, as well as important antagonist properties of the CB1 receptor of cannabinoids. View study
Development of a validated method for the qualitative and quantitative analysis of cannabinoids in plant biomass and medicinal cannabis resin extracts obtained by super-critical fluid extraction. (2019)

The social push for the therapeutic use of cannabis extracts has increased significantly over recent years. The purpose of this study was to close the gap between current methods of biomass analysis and the final therapeutic product by describing a fully developed and validated ultrahigh performance liquid chromatography method with diode array detection (UHPLC-DAD) for the qualification and quantification. of cannabinoids CBDA, CBD, CBN, THC, CBC and THCA, in medicinal cannabis biomass and resin obtained by extraction of supercritical fluids (SFE). View study
Differential role of cannabinoids in the pathogenesis of skin cancer ()

In this study conducted in mice, cannaninoids such as ?9-tetrahydrocannabinol (THC) were able to greatly inhibit the tumor growth of melanomas HCmel12 and B16. The results of this study confirm the value of exogenous cannabinoids for the treatment of melanoma, but do not support the role of the endogenous cannabinoid system in the pathogenesis of skin cancer. View study
Direct suppression of autoreactive lymphocytes in the central nervous system via the CB2 receptor (2008)

It was verified that tetrahydrocannabinol (THC) produced by Cannabis Sativa and found in marijuana has been shown to be immunosuppressant in vivo and in vitro. This research focuses mainly on the function of the immune system and the regulation of effectors of T cells associated with autoimmune inflammation in the central nervous system (CNS). View study
Distinct Neurobehavioural Effects of Cannabidiol in Transmembrane Domain Neuregulin 1 Mutant Mice (2012)

Through this study we want to verify if the mutant neuregulin 1 transmembrane mice (Nrg1 TM HET) respond differently to cannabis (CBD) and if the (CBD) reverts the phenotypes related to schizophrenia expressed by these mice. View study
Dronabinol and marijuana in HIV+ marijuana smokers (2005)

The aim of this study was to compare dronabinol and THC in HIV + marijuana smokers. It was shown that both dronabinol and marijuana produce increased appetite and food intake without producing adverse effects. View study
Drug Reinforcement in a Rat Model of Attention Deficit-Hyperactivity Disorder � The Spontaneously Hypertensive Rat (SHR) (2009)

In this investigation, the study was carried out in a model of attention deficit hyperactivity disorder (ADHD) in rats: the spontaneously hypertensive rat (SHR) using a pharmacological reinforcement. The results reviewed show that the SHR strain is a promising tool for studies on drug addiction and, possibly, its relationship with (ADHD). View study