Epilepsy Medical Cannabis Studies

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Cannabinoids in the Treatment of Epilepsy (2015)

Studies in humans suggest that cannabidiol (CBD) and ?9-THC may have beneficial properties for the treatment of epilepsy. However, these studies are quite limited and therefore it is not possible to draw conclusions about them. If randomized clinical trials show that specific cannabinoids are safe and effective, those preparations should be approved and made available. View study
Cannabis, Cannabinoids and Tinnitus (2014)

Cannabinoids exert anti-epileptic effects in various parts of the brain, but the function of CB1 receptors in the circuits of the dorsal cochlear nuclei suggests that cannabinoids may have the potential to facilitate the increase of neuronal excitation rather than inhibit it, which could aggravate tinnitus. However, more in-depth studies of the endocannabinoid system in the cochlear nucleus and other parts of the central auditory system are needed in order to determine whether or not cannabinoids are beneficial in the treatment of tinnitus. View study
CBD-enriched medical cannabis for intractable pediatric epilepsy; The current Israeli experience (2016)

A study was conducted with the objective of confirming the positive effects of medicinal cannabis enriched with cannabidiol (CBD) in children with epilepsy. As a result of this study, 89% of children reported a reduction in the frequency of seizures. However, 7% of patients reported aggravation of seizures that led to abstinence from CBD. In general, these results are very promising. It is necessary to perform more prospective and well designed clinical trials using medicinal cannabis enriched with CBD. View study
Chronic Administration of Cannabidiol to Healthy Volunteers and Epileptic Patients (1980)

According to the results of this study, cannabidiol (CBD) has the potential to become an antiepileptic drug, as well as having a possible potentiating effect on other antiepileptic drugs. It was found that CBD has a beneficial effect in patients with secondary generalized epilepsy with temporal focus. View study
Drug-drug interaction between clobazam and cannabidiol in children with refractory epilepsy. (2015)

Refractory epilepsy is when epileptic seizures are so frequent that they limit the patient’s ability to live fully according to their desires and their mental and physical capacity. The objective of this study was under an expanded access investigational new drug (IND) trial, cannabidiol (CBD) is being studied as a possible adjuvant treatment of refractory epilepsy in children. It was concluded that (CBD) is a safe and effective treatment of refractory epilepsy in patients receiving treatment with clobazam (CLB). View study
Duration of use of oral cannabis extract in a cohort of pediatric epilepsy patients (2017)

The results of this study highlight the need for rigorous clinical studies to characterize the efficacy and safety of oral cannabis extracts and their use in the treatment of epilepsy, since despite the legalization of the product in the United States, its effectiveness it is not yet clear. View study
Epidiolex (Cannabidiol) in Treatment Resistant Epilepsy (2015)

This study has obtained promising results for Epidiolex (cannabidiol) as a drug for treatment in children with a variety of epilepsy syndromes. It was found that children and young adults with Dravet’s syndrome had the greatest reduction in seizures. More randomized controlled trials are being conducted to support these results. View study
Marijuana Use in Epilepsy: The Myth and the Reality (2015)

In recent years the interest for the use of cannabinoids for the treatment of epilepsy has grown. This review answers the most significant questions that doctors have about the use of cannabis in the treatment of epilepsy. View study
On the application of cannabis in paediatrics and epileptology (2004)

A study about the therapeutic application of THC in children and adolescents with neurodegenerative diseases, epilepsy and other chronic conditions, showed that THC reduced spasticity, provoked improved dystonia, and had anticonvulsive actions. View study
Redistribution of CB1 Cannabinoid Receptors in the Acute and Chronic Phases of Pilocarpine-Induced Epilepsy (2011)

The endogenous cannabinoid system plays a fundamental role in retrograde synaptic communication and controls the propagation of activity in an epileptic network. Changes in the pattern of CB1 cannabinoid receptor expression are associated with the severity of the hippocampal lesion, caused by acute seizures that eventually lead to sclerosis. View study
Report of a parent survey of cannabidiol-enriched cannabis use in pediatric treatment-resistant epilepsy (2013)

This study is based on a survey that shows that parents are using cannabis enriched with CBD for the treatment of severe epilepsy in children, and the beneficial effects of this treatment. View study
The case for medical marijuana in epilepsy (2014)

Charlotte is a girl with Dravet syndrome who appeared in a special on CNN. She started a CBD: THC therapy in parallel with her conventional treatment and experienced an extraordinary reduction in the frequency of her seizures. View study