Medical Cannabis Studies

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Potentiation of the antitumor activity of adriamycin against osteosarcoma by cannabinoid WIN-55,212-2 (2015)

Based on the results obtained in this study, the cannabinoid WIN-55,212-2 is antiproliferative, antimetastatic and antiangiogenic against MG-63 cells in vitro, and in addition, the cannabinoid WIN-55,212-2 can result in a synergistic antitumor action in combination with adriamycin against osteosarcoma. However, further in-depth studies are required to investigate the precise and complete molecular mechanisms of these antitumor activities, and whether this coadministration of cannabinoids and adriamycin could be effectively applied in practice. View study
Preliminary, open label, pilot study of add on oral Delta9 tetrahydrocannabinol in chronic post traumatic stress disorder. (2014)

Many patients with posttraumatic stress disorder (PTSD) achieve but partial remission with currenttreatments.Patients with unremitted PTSD show high rates of substance abuse. Marijuana is often used as compassion addon therapy for treatmentresistant PTSD. The present open-label study evaluates the tolerance and safety of orally absorbable ? (9) tetrahydrocannabinol (THC) for chronic PTSD. View study
Preparation and characterisation of biodegradable microparticles filled with THC and their antitumor efficacy on cancer cell lines (2013)

Cannabinoids have great pharmacological potential despite the difficulties they may present at the time of handling. However, in this work it was possible to efficiently encapsulate D9-tetrahydrocannabinol in polycaprolactone microparticles, which can be administered subcutaneously through a conventional needle. It was demonstrated that a single administration of these microparticles showed an antiproliferative effect during the 9 days of the experiment. In the future, these systems could be used in combination with other anti-cancer drugs or conventional therapies to increase therapeutic efficacy. View study
Presence of functional cannabinoid receptors in human endocrine pancreas (2007)

The stimulation with CB1 was able to increase the secretion of insulin and glucagon, as well as the lipogenesis in the liver and adipose tissue, blocking the incorporation of glucose in the muscle cells, which led to a saving cycle: lower expenditure energy and greater energy storage. The improved release of insulin can help facilitate the incorporation of glucose into the adipocytes, while the improved release of glucagon can maintain high levels of plasma glucose, which favors this saving cycle. Under this hypothesis, CB1 can be considered a new ’thrifty gene’. In light of this possible role, the endocannabinoid system can be considered a promising target for the pharmacological development in diabetes and complicated obesity. View study
Presynaptically Located CB1 Cannabinoid Receptors Regulate GABA Release from Axon Terminals of Specific Hippocampal Interneurons (1999)

There is clear evidence from the results obtained that cannabinoid-mediated modulation of hippocampal interneuron networks operates largely through presynaptic receptors in CCK immunoreactive basket cell terminals. The decrease in GABA release from these terminals is the probable way in which both endogenous and exogenous CB1 ligands interfere with hippocampal network oscillations and related cognitive functions. View study
Prevalence and correlates of cannabis use among athletes-A systematic review. (2016)

The present review focused on identifying possible risk factors associated with the use of marijuana in athletes. It could be concluded that contrary to the image that athletes do not use psychoactive drugs, this review suggests that a number of athletic subgroups have a higher risk of consuming marijuana. View study
Primary Care Behavioral Interventions to Prevent or Reduce Illicit Drug and Nonmedical Pharmaceutical Use in Children and Adolescents: A Systematic Evidence Review for the U.S. Preventive Services Task Force [Internet] (2014)

The present research was based on the systematic study of the evidence on the benefits and harms of important interventions for primary care designed to reduce the use of illicit drugs or the non-medical use of prescription drugs in children and adolescents. View study
Pro-resolution, protective and anti-nociceptive effects of a cannabis extract in the rat gastrointestinal tract (2013)

This research was based on the study of the effect in rats of a simple extract of medicinal cannabis called (MFF) for its ability to promote the resolution of colitis, prevent gastric damage induced by naproxen and decrease gastric distention induced. visceral pain. The results showed that a simple medicinal cannabis extract can significantly improve the resolution of inflammation and lesions, as well as prevent injuries, in the gastrointestinal tract. View study
Prospects for cannabinoid therapies in basal ganglia disorders (2010)

Evidence has been found that supports the idea that cannabinoids that have antioxidant properties and / or the ability to activate receptors (CB2) may represent useful therapeutic tools in Parkinson’s disease (PD) and Huntington’s disease (HD). View study
prostate cancer cell (2010)

Through this study it was possible to obtain evidence that fatty acid amide hydrolase (FAAH) metabolizes ethanolamide eicosapentaenoyl (EPEA) and ethanolamide docosahexaenoyl (DHEA) and that the antiproliferative potencies of these ethanolamides in LNCaP cells can be enhanced by inhibiting this enzyme. The findings suggest that the expression of cannabinoid receptors and (FAAH) in some tumor cells could influence the effectiveness of (DHA) and (EPA) or their ethanolamide derivatives as anticancer agents View study
Protective effects of ?9-tetrahydrocannabinol against N-methyl-D-aspartate-induced AF5 cell death (2005)

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Psychological and psychosocial interventions for cannabis cessation in adults: a systematic review short report (2015)

Cannabis is the most widely used illicit drug in the world. Cannabis dependence is a recognized psychiatric diagnosis. The objective of this research was to systematically review the clinical effectiveness of psychological and psychosocial interventions for the cessation of cannabis in adults who regularly use cannabis. View study