Cancer Medical Cannabis Studies

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A cannabinoid quinone inhibits angiogenesis by targeting vascular endothelial cells (2006)

Cannabidiol hydroxyquinone (HU-331) has a great potential to become an antiangiogenic and anticancer drug. This study demonstrated that HU-331 was able to significantly inhibit angiogenesis at very low concentrations, in addition to significantly decreasing the total area occupied by the vessels in the treated tumors. View study
A pilot clinical study of ?9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme (2006)

Due to its ability to inhibit tumor growth in animals, THC and other cannabinoids have been suggested as antitumor drugs. This is the first clinical study to test the application of THC in human patients with recurrent glioblastoma multiforme. The results demonstrate the safety profile of THC and its action on tumor cells, which establishes the basis for future trials. View study
A selective review of medical cannabis in cancer pain managment. (2017)

Insufficient management of chronic and neuropathic pain associated with cancer adversely affects the patient’s quality of life. The objective of this review was to present a selection of representative clinical studies, which evaluated the efficacy of cannabinoid-based treatments containing tetrahydrocannabinol (THC) and cannabidiol (CBD) to reduce pain associated with cancer. View study
Anandamide Induces Apoptosis in Human Cells via Vanilloid Receptors (2000)

The results of this study indicate that cannabinoid receptors have a protective role against apoptosis induced by endocannabinoid anandamide (AEA) through vanilloid receptors. View study
Anti-proliferative effects of anandamide in human hepatocellular carcinoma cells (2012)

A study demonstrating that endogenous cannabinoid anandamide AEA inhibits the proliferation of cancer cells and induces cellular apoptosis, suggesting its therapeutic potential in the treatment of patients with human hepatocellular carcinoma. View study
Anti-tumoral action of cannabinoids on hepatocellular carcinoma: role of AMPK-dependent activation of autophagy (2011)

Findings that reveal the therapeutic potential of cannabinoids for the treatment of hepatocellular carcinoma, especially in advanced stages. View study
Anti-tumoral action of cannabinoids: Involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation (2000)

THC (the main component of cannabis) induces apoptosis (cell death) of cancer cells in culture. Its intratumoral administration induced a considerable regression of malignant gliomas. View study
Antiangiogenic activity of the endocannabinoid anandamide: Correlation to its tumor-suppressor efficacy (2007)

Anandamide is potentially involved in the control of cancer growth directed both to the proliferation of tumor cells and to the angiogenic stimulation of the vasculature. View study
Anticancer mechanisms of cannabinoids (2016)

There is a lot of evidence that shows how cannabinoids can reduce cancer tumors in animals. These findings already serve as the basis for the development of studies that analyze the therapeutic potential of cannabinoids to fight cancer. View study
Antitumorigenic Effects of Cannabinoids beyond Apoptosis (2009)

Cannabinoids may likewise affect cancer cell angiogenesis, migration, invasion, adhesion, and metastasization. View study
Cannabidiol as potential anticancer drug (2012)

There is emerging evidence to suggest that cannabidiol (CBD) is a potent inhibitor of cancer growth and spread. Its effectiveness is linked to its ability to target multiple cellular pathways that control tumorigenesis through the modulation of different intracellular signals depending on the type of cancer considered. View study
Cannabidiol Enhances the Inhibitory Effects of ?9-Tetrahydrocannabinol on Human Glioblastoma Cell Proliferation and Survival (2010)

Adding cannabidiol to ?9-THC may improve the effectiveness of ?9-THC in the treatment of glioblastoma in patients with cancer. When treating the cells with both compounds it was observed that these acted synergistically to inhibit cell proliferation. View study