Neuro-Protective-and-Neuro-Generative Medical Cannabis Studies

Activation of Type 1 Cannabinoid Receptor (CB1R) Promotes Neurogenesis in Murine Subventricular Zone Cell Cultures (2013)

These results demonstrate that the activation of the endocannabinoid receptor CB1R induces the proliferation, self-renewal and neuronal differentiation of the cell cultures of the neonatal subventricular zone in animal models. View study
An endogenous cannabinoid (2-AG) is neuroprotective after brain injury (2001)

Here we show that, after an injury to the brain of a mouse, Arachidonoyl glycerol (2-AG) may have a neuroprotective role in which the cannabinoid system is involved. We found a significant reduction of cerebral edema, better clinical recovery, reduced infarct volume and reduced hippocampal cell death compared to controls. View study
Cannabidiol administration after hypoxia-ischemia to newborn rats reduces long-term brain injury and restores neurobehavioral function (2012)

CBD has been shown to have short-term neuroprotective effects in the immature brain, suggesting that it could be used as a neuroprotective agent for neonatal hypoxiaeischemia. View study
Cannabidiol inhibits pathogenic T cells, decreases spinal microglial activation and ameliorates multiple sclerosis-like disease in C57BL/6 mice (2011)

The cannabidiol (CBD) is, potentially, a safe and effective alternative for alleviating neuroinflammation and neurodegeneration. CBD ameliorates clinical signs of experimental autoimmune encephalomyelitis in mice, immunized against myelin oligodendrocyte glycoprotein. Suppression of microglial activity and T�cell proliferation by CBD appeared to contribute to these beneficial effects. View study
Cannabinoid receptor CB1 mediates baseline and activity-induced survival of new neurons in adult hippocampal neurogenesis (2010)

This study states that some of the positive therapeutic characteristics of CBD-based compounds could be explained by the pro-neurogenic effects of CBD. View study
Cannabinoids and Neuroprotection in Basal Ganglia Disorders (2007)

A promising hope lies in the therapeutic potential of cannabinoids as neuroprotective against neurodegenerative disorders such as chronic Parkinson’s or Huntington’s diseases. View study
Cannabinoids in Neurodegenerative Disorders and Stroke/Brain Trauma: From Preclinical Models to Clinical Applications (2015)

This study states that cannabinoid-based drugs can serve as a new therapy capable of delaying / stopping neurodegeneration in acute and chronic neurodegenerative conditions. View study