Medical Cannabis Studies

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Psychopathological and cognitive effects of therapeutic cannabinoids in multiple sclerosis: a double-blind, placebo controlled, crossover study (2009)

This research focused on studying possible psychopathological symptoms and cognitive deficits, the induction of abuse, as well as the general tolerability and effects on quality of life, fatigue and motor function in patients with multiple sclerosis (MS) with cannabis treated with a cannabis plant extract in free doses (Sativex). View study
Psychosocial interventions for cannabis use disorder (2016)

Psychosocial intervention, compared to minimal treatment controls, reduces the frequency of use and severity of cannabis dependence and eliminates it, at least in the short term. View study
Randomized, controlled trial of cannabis-based medicine in central pain in multiple sclerosis (2005)

The results of this study provide clear evidence that the use of cannabis is effective in reducing pain and sleep disturbance in patients with central neuropathic pain related to multiple sclerosis. View study
Recent advances in cannabinoid receptor agonists and antagonists ()

The term cannabinoid includes analogues of the natural components of cannabis, endocannabinoids and a wide range of chemical structures. The objective of the present review is to show a general description of recent advances in the chemistry of cannabinoids with special emphasis on the patent literature. View study
Receptor-dependent and receptor-independent endocannabinoid signaling: A therapeutic target for regulation of cancer growth (2013)

Cannabinoids are a class of pharmacological compounds that offer better therapeutic applications as anti-tumor drugs depending on their ability to inhibit the proliferation of tumor cells and survival.This review of recent work provides a general description of the main findings about the effects of endogenous and / or synthetic cannabinoids in breast and prostate cancers. Information is also given on the receptor-independent mechanisms of the anticancer effects of cannabinoids under in vitro and in vivo conditions. View study
Redistribution of CB1 Cannabinoid Receptors in the Acute and Chronic Phases of Pilocarpine-Induced Epilepsy (2011)

The endogenous cannabinoid system plays a fundamental role in retrograde synaptic communication and controls the propagation of activity in an epileptic network. Changes in the pattern of CB1 cannabinoid receptor expression are associated with the severity of the hippocampal lesion, caused by acute seizures that eventually lead to sclerosis. View study
Regulation of nausea and vomiting by cannabinoids (2010)

An important advance in the control of acute emesis in the treatment of chemotherapy was the finding that blocking a subtype of the 5-hydroxytryptamine (5-HT) receptor, the 5-HT3 receptor, could suppress the acute emetic response. Cannabis is taken as self-medication in patients with inflammatory bowel disease for symptomatic relief. The present investigation focused on the study of the regulation of nausea and vomiting by cannabinoids. View study
Relationships between eicosanoids and cannabinoids- Are eicosanoids cannabimimetic agents ()

Cannabis has been used for medical and recreational purposes with a long history dating from 5000 BC. However, we have learnt more about cannabis in the last three decades than in all the previous centuries.The present review focused on summarizing recent advances in cannabinoid chemistry with a special emphasis on patent literature. View study
Report of a parent survey of cannabidiol-enriched cannabis use in pediatric treatment-resistant epilepsy (2013)

This study is based on a survey that shows that parents are using cannabis enriched with CBD for the treatment of severe epilepsy in children, and the beneficial effects of this treatment. View study
Review on psychotherapeutic interventions for cannabis disorders (2004)

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Role of CB2 receptors in social and aggressive behavior in male mice (2014)

This research was based on examining the role of the cannabinoid CB2r in social and aggressive behavior, using male CB1KO mice. View study
Role of Endocannabinoids and Cannabinoid-1 Receptors in Cerebrocortical Blood Flow Regulation (2013)

Endocannabinoids (EC) are endogenous bioactive lipid mediators that exert many of their effects in mammals through their receptors coupled to specific G proteins [1]. The present research aims to study the role of endocannabinoids and cannabinoid-1 receptors in the regulation of cerebrocortical blood flow View study