Medical Cannabis Studies

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Cannabinoid facilitation of fear extinction memory recall in humans (2013)

The results of this study provide the first evidence that the pharmacological improvement of learning by extinction is feasible in humans who use modulators of the cannabinoid system, which may justify further development and clinical trials. View study
Cannabinoid inhibits HIV-1 Tat-stimulated adhesion of human monocyte-like cells to extracellular matrix proteins (2014)

Based on the results of this study there is evidence that cannabinoids can be used as a therapeutic agent for the eradication of neuroinflammation related to the influx of leukocytes by HIV through the blood-brain barrier (BBB). View study
Cannabinoid Modulation of Neuroinflammatory Disorders (2011)

Due to their peculiar chemistry, cannabinoids have imposed a challenge on researchers. Cannabinoids have so many benefits that even to date it is impossible to prove or discard each one of them. For now, science aims to understand how cannabinoid compounds are associated with neuroinflammation and how cannabis-based medicine can help millions of patients around the world. The development of safe and effective medicines based on cannabis must overcome the risk of adverse effects. View study
Cannabinoid receptor 1 is a potential drug target for treatment of translocation-positive rhabdomyosarcoma (2009)

According to the results of this study, cannabinoid receptors have been shown to have antitumor properties in vitro and, for the first time, in vivo. This could represent a possible new treatment strategy that could improve the results in translocation-positive rhabdomyosarcoma. View study
Cannabinoid receptor 2 as a potential therapeutic target in rheumatoid arthritis (2014)

This research was done on the therapeutic effect of cannabinoid selective CB2 receptor agonist on arthritis. This study was able to conclude that a selective CB2 agonist can inhibit the production of inflammatory mediators of FLS and osteoclastogenesis, it could be for this reason a new therapy for rheumatoid arthritis (RA) View study
Cannabinoid Receptor 2-Mediated Attenuation of CXCR4-Tropic HIV Infection (2012)

It is possible that in the late stages of HIV-1 disease (AIDS), the clinical use of CBR2 agonists will have positive effects against tropic CXCR4 viruses. View study
Cannabinoid receptor activation induces apoptosis through tumor necrosis factor alpha-mediated ceramide de novo synthesis in colon cancer cells (2008)

Recently, cannabinoids have been proposed as possible antitumor agents. This study investigates the expression of the two cannabinoid receptors, CB1 and CB2, in colorectal cancer, revealing for the first time that TNF-a acts as a link between the activation of the cannabinoid receptor and the production of ceramide. View study
Cannabinoid receptor activation leads to massive mobilization of myeloid-derived suppressor cells with potent immunosuppressive properties (2010)

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Cannabinoid Receptor Agonist as an Alternative Drug in 5-Fluorouracil-resistant Gastric Cancer Cells (2013)

The cannabinoid agonist WIN 55,212-2 is able to induce cytotoxicity in gastric cancer cells resistant to 5-FU. These results indicate that cannabinoids have potential to be used as therapy against gastric cancer resistant to 5-FU. View study
Cannabinoid Receptor Agonist-induced Apoptosis of Human Prostate Cancer Cells LNCaP Proceeds through Sustained Activation of ERK12 Leading to G1 Cell Cycle Arrest (2006)

These data suggest that cannabinoid receptor agonists should be considered as novel agents for the treatment of prostate cancer, considering that the expression levels of both CB1 and CB2 cannabinoid receptors are higher in human prostate cancer cells than in epithelial cells. of normal prostate, View study
Cannabinoid receptor as a novel target for the treatment of prostate cancer (2015)

The cannabinoids, the active components of Cannabis sativa, have received great interest due to their multiple pharmacological properties, such as the inhibition of cell growth, the anti-inflammatory effects and the regression of tumors. Our results suggest that various non-habit forming cannabinoid receptor agonists could be developed as new therapeutic agents for the treatment of prostate cancer. View study
Cannabinoid receptor CB1 mediates baseline and activity-induced survival of new neurons in adult hippocampal neurogenesis (2010)

This study states that some of the positive therapeutic characteristics of CBD-based compounds could be explained by the pro-neurogenic effects of CBD. View study