Medical Cannabis Studies

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Cannabinoid WIN-55,212-2 mesylate inhibits interleukin-1b induced matrix metalloproteinase and tissue inhibitor of matrix metalloproteinase expression in human chondrocytes (2013)

In this study we try to determine how cannabinoid mesylate WIN-55,212-2 inhibits matrix metalloproteinase is activated by interleukin-1b and the tissue inhibitor of matrix metalloproteinase expression in human chondrocytes. The results show that the actions of WIN-55 suggest a mechanism by which cannabinoids can act to prevent the breakdown of cartilage in arthritis. View study
Cannabinoid-associated cell death mechanisms in tumor models (Review) (2012)

Cannabinoids have been shown to possess certain anti-cancer qualities. A more in-depth exploration of the molecular mechanisms induced by cannabinoids on cancer cells could contribute to the development of safe and effective treatments in cancer therapy. View study
CANNABINOID-BASED DRUGS AS ANTI-INFLAMMATORY THERAPEUTICS (2005)

Drugs derived from cannabis have immunosuppressive and anti-inflammatory properties, and may have great therapeutic utility in chronic diseases. View study
Cannabinoid-induced apoptosis in immune cells as a pathway to immunosuppression (2010)

This research focused on the study of the apoptotic mechanisms of cannabinoid-mediated immunosuppression in different immune cell populations and we will evaluate how the activation of CB2 gives a novel therapeutic modality against inflammatory and autoimmune diseases, as well as malignant neoplasms of the immune system, without exercising the unpleasant psychotropic View study
Cannabinoid-induced conditioned place preference in the spontaneously hypertensive rat�an animal model of attention deficit hyperactivity disorder (2008)

This research was based on comparing the motivational effects of the synthetic cannabinoid agonist WIN55,212-2 (WIN) in adolescent and adult rats with spontaneous hypertension (SHR), a validated animal model of attention deficit / hyperactivity disorder (ADHD) and rats Wistar, which represent a normal genetically heterogeneous population. It was possible to conclude in this study that the contrasting effects of WIN in Wistar and SHR, and the greater resistance of adolescent rats to the aversive and satisfactory effects of WIN in these two strains suggest that both adolescence and the profile similar to ADHD that presents the SHR strain are factors that influence the motivational properties of cannabinoids. View study
Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors (1999)

This investigation was based on the study in rats to verify the mesen- tial vasodilation induced by cannabinoids through an endothelial site different from the CB1 or CB2 receptors. View study
Cannabinoid-related agents in the treatment of anxiety disorders- current knowledge and future perspectives (2013)

In this article we review the evidence that cannabis products have different effects on the regulation of emotions. It has been mentioned that tetrahydrocannabinol (THC) and other herbal, synthetic and endogenous cannabinoids can decrease or increase the behaviors related to fear and anxiety in humans and animals used in experiments. The difference in responses in each individual is due to several genetic and environmental factors and to THC concentrations within the plant. View study
Cannabinoids and Cancer (2005)

Cannabinoids have some anticancer properties, in addition to stimulating appetite, attenuate pain, inhibit nausea and vomiting. It is possible that cannabinoids can represent a new type of drugs with great utility in the fight against cancer, slowing its growth, inhibiting angiogenesis and metastatic spread of cancer cells. View study
Cannabinoids and cancer: pros and cons of an antitumour strategy (2006)

Cannabinoids have the ability to selectively affect tumor cells more than their untransformed counterparts that may even be protected from cell death. These findings suggest that the cannabinoid system represents a promising target for cancer treatment. View study
Cannabinoids and ceramide: Two lipids acting hand-by-hand (2005)

This study suggests that endocannabinoids constitute a new family of lipid signaling cues responsible for the regulation of the development and survival of neuronal cells, and provide a conceptual and mechanical basis for the effects of cannabinoids derived from marijuana. These findings provide a new conceptual view of how cannabinoids act and pose interesting physiological and therapeutic questions. However, more research is needed to determine the real impact of cannabinoids on brain development and the possible participation of ceramide in these events. View study
Cannabinoids and Dementia: A Review of Clinical and Preclinical Data (2010)

Many studies show that cannabinoids are suitable for treating the symptoms of dementia, especially in in vitro tests, however, much more research and clinical trials are needed in vivo and in humans to corroborate them. View study
Cannabinoids and multiple sclerosis (2002)

This study shows the increasing amount of evidence indicating that cannabis and individual cannabinoids can be effective in eradicating certain symptoms of multiple sclerosis and spinal cord injuries, including spasticity and pain. View study