Medical Cannabis Studies

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Cannabis: An ancient friend or foe? What works and doesn't work (2019)

Cannabis has been cultivated by mankind for a multitude of uses over a period of thousands of years. This review focused on exploring how our relationship with the cannabis plant has evolved during this period of time, including the use of recreational cannabis and its medicinal properties. As well as summarizes much of the evidence on what is known about the long-term effects of exposure to cannabis in the womb. View study
Care and Feeding of the Endocannabinoid System: A Systematic Review of Potential Clinical Interventions that Upregulate the Endocannabinoid System (2014)

In this investigation it was discovered that CB2 receptors can form heteromers with CB1 receptors in transfected neuronal cells and in pineal gland of rat brain, nucleus accumbens and pale globe. In general, the data obtained in this research illuminates the mechanism by which CB2 receptors can negatively modulate CB1 receptor function. View study
CB2 cannabinoid receptors as an emerging target for demyelinating diseases: from neuroimmune interactions to cell replacement strategies (2008)

In this research, the study of current knowledge and the understanding of the usefulness of cannabinoids as therapeutic molecules for demyelinating diseases mediated by inflammation is carried out. View study
CBD inhibits angiogenesis by multiple mechanisms (2012)

Cannabidiol can inhibit angiogenesis (a physiological process that consists in the formation of new blood vessels from pre-existing vessels) through different mechanisms. Based on the results of this study, it is demonstrated that cannabidiol has the potential to be used as an effective agent in cancer therapy. View study
CBD-enriched medical cannabis for intractable pediatric epilepsy; The current Israeli experience (2016)

A study was conducted with the objective of confirming the positive effects of medicinal cannabis enriched with cannabidiol (CBD) in children with epilepsy. As a result of this study, 89% of children reported a reduction in the frequency of seizures. However, 7% of patients reported aggravation of seizures that led to abstinence from CBD. In general, these results are very promising. It is necessary to perform more prospective and well designed clinical trials using medicinal cannabis enriched with CBD. View study
Ceramide: a new second messenger of cannabinoid action (2001)

Taking into account the emergent role of ceramide in the control of cell fate, in addition to the growing range of functions modulated by cannabinoids, it is possible to say that the cannabinoid-ceramide connection could generate interesting physiological implications and therapeutic possibilities. View study
Characterisation of the Cannabinoid Receptor System in Synovial Tissue and Fluid in Patients With Osteoarthritis and Rheumatoid Arthritis (2007)

This research showed that cannabinoids (CB1) and (CB2) and cannabis-based drugs have a therapeutic potential in inflammatory diseases, including rheumatoid arthritis (RA) and osteortritis (OA). The final data indicate that the receptor system present in the synovium of the joints can be a therapeutic target for the treatment of inflammation and pain related to (OA) and (RA). View study
Characterization of P-glycoprotein Inhibition by Major Cannabinoids from Marijuana (2005)

Through this study we want to investigate the possible interaction with P-glycoprotein (Pgp) with the main cannabinoids of marijuana. The findings found indicate that the CBD inhibits the transport of drugs measured by P-gp, which suggests that the CBD could act in the absorption and elimination of other co-administered compounds that are substrates of P-gp. View study
Chemistry, Metabolism, and Toxicology of Cannabis- Clinical Implications (2012)

This review focused on summarizing the properties of cannabis and its derivatives, and discuss the implications of its use with emphasis on bioavailability, detection limit, period of entrainment and passive inhalation, important factors for detection and diagnosis. View study
Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer (2012)

CBD exerts antioxidant, intestinal, anti-inflammatory actions and potentially beneficial mechanisms for colon carcinogenesis. This study investigates its chemopreventive effects and the reduction of cell proliferation through multiple mechanisms. View study
Chronic Administration of Cannabidiol to Healthy Volunteers and Epileptic Patients (1980)

According to the results of this study, cannabidiol (CBD) has the potential to become an antiepileptic drug, as well as having a possible potentiating effect on other antiepileptic drugs. It was found that CBD has a beneficial effect in patients with secondary generalized epilepsy with temporal focus. View study
Chronic blockade of cannabinoid CB2 receptors induces anxiolytic-like actions associated with alterations in GABA(A) receptors (2011)

This study supports the key role of CB2 receptors in the regulation of anxiety and, in addition, the effectiveness of the AM630 receptor antagonist further strengthens the potential of CB2 for the treatment of anxiety-related disorders. View study