Medical Cannabis Studies

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High level of cannabinoid receptor 1, absence of regulator of G protein signalling 13 and differential expression of Cyclin D1 in mantle cell lymphoma (2003)

This research was done in relation to mantle cell lymphoma (MCL). In order to identify the tumor characteristics that improve the understanding of the biology of MCL, oligonucleotide microarray analyzes were used to define specific gene expression profiles. View study
Id-1 Is a Key Transcriptional Regulator of Glioblastoma Aggressiveness and a Novel Therapeutic Target (2012)

This research showed that the transcriptional regulator Id-1 plays a critical role in the modulation of the invasiveness of glioblastoma cell lines and primary glioblastoma cells. It should be mentioned that the genetic destruction of Id-1 leads to a considerable increase in survival in an orthotopic model of human glioblastoma. The results show that Id-1 regulates multiple pathways of tumor promotion in glioblastoma and that drugs targeting Id-1 represent a new strategy to improve therapy and the outcomes of patients with glioblastoma. View study
Identification of cytochrome P450 enzymes responsible for metabolism of cannabidiol by human liver microsomes (2011)

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Identification of Psychoactive Degradants of Cannabidiol in Simulated Gastric and Physiological Fluid (2016)

This research seeks to identify the psychoactive degradants of cannabidiol in simulated gastric and physiological fluids. It was concluded that the simulated gastric fluid SGF converts cannabidiol (CBD) into the psychoactive components D9 -THC and D8 -THC. View study
Immunoactive effects of cannabinoids: considerations for the therapeutic use of cannabinoid receptor agonists and antagonists (2010)

The immunological effects of cannabinoids should be considered in the context of each prescription decision. Evidence is shown that the immunological effects of cannabinoid receptor agonists and antagonists are quite relevant to the spectrum of disorders for which the therapeutic products of cannabinoids are currently offered. View study
Immunohistochemical analysis of cannabinoid receptor 1 expression in steatotic rat livers (2015)

In the present study, immunohistochemical analysis of the expression of the cannabinoid receptor 1 in steatotic rat livers was performed. It was observed that CB1 receptors are overexpressed in areas with steatosis, and show that CB1 in hepatocytes helps the formation of steatosis in rats. View study
Impact of Medical Cannabis on Patient-Reported Symptoms for Patients With Cancer Enrolled in Minnesota's Medical Cannabis Program. (2019)

Minnesota’s medical cannabis program is unique, in that it routinely collects patient-reported scores on symptoms. The objective of this article was to focus on changes in the severity of symptoms reported by cancer patients during the first 4 months of participation in this program. View study
In vitro and in vivo efficacy of non-psychoactive cannabidiol in neuroblastoma (07/01/05)

The results of this study confirm the antitumourigenic actions of the active compound cannabidiol (cbd) in neuroblastoma cells (nbl), and support its exploitation as an efficient drug in the treatment against cancer (nbl). View study
In vitro antibacterial activity of Cannabis sativa leaf extracts to some selective pathogenicbacterial strains (2014)

The results of these studies indicate the antibacterial activity of leaf extract Cannabis sativa. It has been shown that the minimum inhibitory effect of C. sativa leaf extract is due to certain compounds present in C.sativa. Additional research is recommended to identify the compounds responsible for their activity that could be used as medicines to control many diseases in the world. View study
Increasing Antiproliferative Properties of Endocannabinoids in N1E-115 Neuroblastoma Cells through Inhibition of Their Metabolism (2011)

This research focused on the study of the antiproliferative properties of endocannabinoids in neuroblastoma N1E-115 cells by inhibiting their metabolism. The results found in this study give us clear evidence of targeting the endocannabinoid system to treat cancer. View study
Induction of Apoptosis by Cannabinoids in Prostate and Colon Cancer Cells Is Phosphatase Dependent (2011)

Cannabinoid receptor agonists induce phosphatases and phosphatase-dependent apoptosis in cancer cell lines; however, the role of the CB receptor in mediating this response depends on the ligand. View study
Inhibition of Cancer Cell Invasion by Cannabinoids via Increased Expression of Tissue Inhibitor of Matrix Metalloproteinases-1 (2008)

According to the results of this research, it can be affirmed that cannabinoids can offer a therapeutic option in the treatment of highly invasive cancers. View study