Endocannabinoid-System-Ecs Medical Cannabis Studies

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Identification of cytochrome P450 enzymes responsible for metabolism of cannabidiol by human liver microsomes (2011)

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Mitochondria: a possible nexus for the regulation of energy homeostasis by the endocannabinoid system (07/01/05)

This research focuses on studying the different ways in which ECS can impact mitochondrial abundance and / or oxidative capacity, and link these findings with the obesity-induced perturbations in metabolic function View study
Neuropharmacology of the Endocannabinoid Signaling System-Molecular Mechanisms, Biological Actions and Synaptic Plasticity (2007)

The present investigation focused on new information about the endocannabinoid signaling system in the brain. As well as in the molecular mechanisms, biological actions and synaptic plasticity. View study
Pharmacokinetics and metabolism of the plant cannabinoids, delta9-tetrahydrocannabinol, cannabidiol and cannabinol ()

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Recent advances in cannabinoid receptor agonists and antagonists ()

The term cannabinoid includes analogues of the natural components of cannabis, endocannabinoids and a wide range of chemical structures. The objective of the present review is to show a general description of recent advances in the chemistry of cannabinoids with special emphasis on the patent literature. View study
Relationships between eicosanoids and cannabinoids- Are eicosanoids cannabimimetic agents ()

Cannabis has been used for medical and recreational purposes with a long history dating from 5000 BC. However, we have learnt more about cannabis in the last three decades than in all the previous centuries.The present review focused on summarizing recent advances in cannabinoid chemistry with a special emphasis on patent literature. View study
Role of the Cannabinoid System in Pain Control and Therapeutic Implications for the Management of Acute and Chronic Pain Episodes (2006)

Cannabis extracts and synthetic cannabinoids are still considered illegal substances. Studies suggest that they can be useful for treating various diseases, including those related to acute or chronic pain. The objective of this review was to examine the promising indications of cannabinoid receptor agonists to relieve episodes of acute and chronic pain. View study
Role of the Endocannabinoid System in the Neuroendocrine Responses to Inflammation (2014)

For several years the endocannabinoid system has been recognized as an important neuromodulator system whose main functions are to exercise and maintain the homeostasis of the body. The present review focused on the actions of endocannabinoids on the neuroendocrine response to inflammation and infection. View study
Targeting the endocannabinoid system with cannabinoid receptor agonists- pharmacological strategies and therapeutic possibilities (2012)

The endocannabinoid system consists of at least two types of receptor coupled to the G protein, CB1 cannabinoid and CB2 receptors, ofendogenous agonists for these receptors known as endocannabinoids and include anandamide and 2-arachidonoyl glycerol, and the processes responsible for endocannabinoids. In the present review, several possible additional therapeutic targets for cannabinoid receptor agonists are mentioned. View study
The Emerging Role of the Endocannabinoid System in Endocrine Regulation and Energy Balance (2008)

During these last years, the endocannabinoid system has emerged as a highly relevant issue in the scientific community. The cannabinoid receptors, called CB1 receptor and CB2 receptor, first discovered as molecular targets of the psychotropic component of the Cannabis sativa plant, participate in the physiological modulation of many central and peripheral functions. This research aimed to study the emerging role of the endocannabinoid system in endocrine regulation and energy balance View study
The endocannabinoid system and migraine ()

The recently discovered endocannabinoid system (ECS), which includes endocannabinoids and the proteins that metabolize and bind them, has been implicated in multiple regulatory functions in both health and disease. Several studies have suggested that (ECS) is involved centrally and peripherally in the processing of pain signals. The present review will aim to describe experimental and clinical data that, intriguingly, demonstrate the link between endocannabinoids and migraine, a neurovascular disorder characterized by recurrent episodes and caused by the abnormal use of sensory information due to peripheral sensitization and / or central. View study
The Endocannabinoid System as an Emerging Target of Pharmacotherapy (2006)

Marijuana, or cannabis, is the most widely used illicit drug in Western societies and also the one with the longest recorded history of human use. However, the ability of extracts from the hemp plant (Cannabis sativa) to cause a variety of medicinal effects unrelated to its psychoactive properties had been recognized as early as the third millennium BC. This study shows a global view about the current state of knowledge of the endocannabinoid system as an objective of pharmacotherapy. View study