Medical Cannabis Studies

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Targeting the endocannabinoid system with cannabinoid receptor agonists- pharmacological strategies and therapeutic possibilities (2012)

The endocannabinoid system consists of at least two types of receptor coupled to the G protein, CB1 cannabinoid and CB2 receptors, ofendogenous agonists for these receptors known as endocannabinoids and include anandamide and 2-arachidonoyl glycerol, and the processes responsible for endocannabinoids. In the present review, several possible additional therapeutic targets for cannabinoid receptor agonists are mentioned. View study
THC:CBD Observational Study Data: Evolution of Resistant MS Spasticity and Associated Symptoms (2016)

The prospective observational mobility improvement study (MOVE) 2 is collecting real-life clinical outcome data in patients with spasticity of multiple sclerosis (MS) resistant to treatment treated with Tetrahydrocannabinol (THC): CBD in orumocosal spray in practice usual clinic. It was concluded that this analysis has been of great benefit, since this provisional analysis has allowed us to better define the place in THC therapy: CBD orumocosal spray within the context of the daily management of our patients with MS spasticity. View study
The Antitumor Activity of Plant-Derived Non-Psychoactive Cannabinoids (2015)

This research will aim to study the mechanisms by which non-psychoactive cannabidiol (CBD) and other cannabinoids derived from plants are inefficient to activate cannabinoid receptors, inhibit the viability of tumor cells, invasion, metastasis, angiogenesis and the stem-like potential of cancer cells. View study
The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system ()

Cannabidiol (CBD), the main non-psychotomimetic component of the Cannabis sativa plant, exerts therapeutically promising effects on human mental health. The objective of this study was to investigate the possible involvement of hippocampal neurogenesis in the anxiolytic effect of (CBD) in mice subjected to 14 days of chronic unpredictable stress (CUS).The findings support that the anxiolytic effect of chronic administration of (CBD) in stressed mice depends on its proneurogenic action in the adult hippocampus by facilitating endocannabinoid-mediated signaling. View study
The Cannabinoid Agonist Win55212 Reduces Brain Damage in an In Vivo Model of Hypoxic-Ischemic Encephalopathy in Newborn Rats (2007)

Neonatal hypoxic-ischemic encephalopathy (HIEI) is a devastating condition for which effective therapeutic treatments are not yet available. Through this study we want to test if cannabinoids could reduce the brain damage induced by hypoxiaquemia (HI) in newborn rats. View study
The cannabinoid receptor agonist WIN 55-212-2 facilitates the extinction of contextual fear memory and spatial memory in rats (2006)

Previous studies demonstrated that pharmacological blockade of CB1 cannabinoid receptors decreases the extinction of conditioned fear and spatial memory in rodents.The objective of this study was to evaluate the effects of the cannabinoid agonist WIN 55,212-2 (WIN) and the cannabinoid antagonist SR 147778 (SR) on the extinction of contextual fear. View study
The cannabinoids: An overview. Therapeutic implications in vomiting and nausea after cancer chemotherapy, in appetite promotion, in multiple sclerosis and in neuroprotection (2001)

The present article explains recent advances in the understanding of the molecular basis of cannabis action, including the identification of CB1 and CB2 cannabinoid receptors, as well as the therapeutic implications in vomiting and nausea after cancer chemotherapy. , in the promotion of appetite, in multiple sclerosis and in neuroprotection. View study
The case for medical marijuana in epilepsy (2014)

Charlotte is a girl with Dravet syndrome who appeared in a special on CNN. She started a CBD: THC therapy in parallel with her conventional treatment and experienced an extraordinary reduction in the frequency of her seizures. View study
The CB2 cannabinoid receptor signals apoptosis via ceramide-dependent activation of the mitochondrial intrinsic pathway (2005)

9-Tetrahydrocannabinol and other cannabinoids exert pro-apoptotic actions on tumor cells through the cannabinoid receptor CB2.The results of this investigation show that CB2 receptor activation signals apoptosis via ceramide-dependent stimulation of the mitochondrial intrinsic pathway. View study
The current status of artisanal cannabis for the treatment of epilepsy in the United States (2017)

This study presents data on the efficacy and adverse effects of artisanal cannabis in patients with epilepsy in the states of Washington, California and Maine. View study
The effect of cannabichromene on adult neural stem-progenitor cells (2013)

The objective of this research was to clarify the effect of the main non-THC phytocannabinoids on the fate of adult stem cell progenitor cells (CPNP), which are a necessary component of brain function in both health and pathology. View study
The effect of cannabis on tremor in patients with multiple sclerosis ()

Disabling tremor is common in patients with multiple sclerosis (MS). The objective was to detect a significant functional improvement of 50% in the tremor index. It was possible to conclude according to the results that the Cannbis extract does not produce a significant functional improvement in the tremor associated with (EM). View study