Medical Cannabis Studies

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The orphan receptor GPR55 is a novel cannabinoid receptor (2007)

It was possible to conclude through the obtained data that the orphan receiver GPR55.es is a new cannabinoid receptor, and its ligand profile with respect to CB1 and CB2 View study
The pattern of neurodegeneration in Huntington's disease: a comparative study of cannabinoid, dopamine, adenosine and GABAA receptor alterations in the human basal ganglia in Huntington's disease (2000)

The aim of this study was to investigate the sequence and pattern of neurodegeneration in Huntington’s disease, for which changes in the cannabinoid receptors CB1, dopamine D1 and D2, adenosine A2a and GABAA were studied in the basal ganglia at baseline (grade 0 ), intermediate (grade 1, 2 neuropathological grades) and advanced (grade 3) of Huntington’s disease. View study
The Pharmacological Basis of Cannabis Therapy for Epilepsy (2016)

Essay on the pharmacological and therapeutic fundamentals of cannabis, with a focus on the endocannabinoid mechanisms underlying the emerging neurotherapeutics of CBD in epilepsy. View study
The relationship between cannabis and male infertility, sexual health, and neoplasm: a systematic review. (2019)

The purpose of this manuscript was to systematically review the available literature describing the effects of marijuana on male infertility, sexual health and urological neoplasms. The results suggest an impact on health and urological disease. Long-term prospective studies are necessary for a more detailed explanation of these effects. View study
The Relationship between Marijuana Use Prior to Sex and Sexual Function in Women. (2019)

The purpose of this research was to evaluate the perceptions of women about the effect of marijuana use before sexual activity. The results of the study allow us to conclude that marijuana seems to improve satisfaction with orgasm. A better understanding of the role of the endocannabinoid system in women is important, because there is little literature and could help the development of treatments for female sexual health. View study
The Risks and Benefits of Cannabis in the Dermatology Clinic. (2017)

The purpose of this review was to summarize some of the studies and reports on the medicinal uses of cannabis in the dermatology clinic and some of the side effects that can occur more frequently to dermatologists as the use of cannabis increases. View study
The role of endocannabinoid signaling in the molecular mechanisms of neurodegeneration in Alzheimer's disease (2014)

In this study, we summarize the role of endocannabinoid signaling in Alzeimer disease and the probable mechanisms through which modulators of the endocannabinoid system provide their effects, thus highlighting how this objective could provide more advantages than other therapeutic objectives. View study
The role of endogenous cannabinoids in the hypothalamo-pituitary-adrenal axis regulation (2004)

Exogenous cannabinoids affect multiple hormonal systems, including the hypothalamic-pituitary-adrenocortical (HPA) axis. This research focused on evaluating the role of endogenous cannabinoids in axis regulation (HPA) by studying knockout mice for the CB1 (KO) and wild type (WT) receptor. View study
The role of the endocannabinoid system in eating disorders- pharmacological implications (2012)

Derivatives of cannabis sativa, such as marijuana and hashish, as well as D-9-tetrahydrocannabinol (THC), the main psychoactive component of the plant, have been known for a long time to stimulate appetite. This research focused on the study of brain circuits where the endocannabinoid system (eCB) plays an important role, such as those related to feeding behavior and gratifying properties of food. View study
The serine hydrolases MAGL, ABHD6 and ABHD12 as guardians of 2-arachidonoylglycerol signalling through cannabinoid receptors (2011)

Lipid molecules not only serve as building blocks of the Central nervous system (CNS) but are being increasingly appreciated as physiological mediators of signal transduction.The endocannabinoid 2 arachidonoylglycerol (2-AG) is a lipid mediator involved in various physiological processes. In this study we reviewed recent research on monoacylglycerol lipase (MAGL), ABHD6 and ABHD12, three serine hydrolases that togetheraccount for approx. 99% of cerebral hydrolase activity 2-AG. View study
The Therapeutic Potential of Cannabis and Cannabinoids (2012)

This study focused on the review of the therapeutic potential of cannabis and cannabinoids. it could be concluded that there is clear evidence that cannabinoids are useful for the treatment of various medical conditions. View study
The therapeutic potential of novel cannabinoid receptors (2009)

In this research the therapeutic value of the new cannabinoid receptors will be reviewed, and we will discuss their true belonging to the endocannabinoid signaling system. View study