Medical Cannabis Studies

• View All (505)

The effects of cannabidiol and its synergism with bortezomib in multiple myeloma cell lines. A role for transient receptor potential vanilloid type-2 (2014)

Multiple myeloma (MM) is a plasma cell (PC) malignancy characterized by the accumulation of a monoclonal PC population in the bone marrow (BM). This research was based on the study of the effects of cannabidiol and its synergism with bortezomib in multiple myeloma cell lines. View study
The effects of cannabidiol and tetrahydrocannabinol on motion-induced emesis in Suncus murinus (2012)

The results of this investigation show how compared to cannabidiol, cannabidiol acid (CBDA), shows a higher potency to prevent vomiting in shrews and nausea in rats and to improve the activation of the 5-HT1A receptor, View study
The Effects of Cannabis Among Adults With Chronic Pain and an Overview of General Harms: A Systematic Review. (2017)

Cannabis is increasingly available for the treatment of chronic pain, but its efficacy remains uncertain. This research was aimed at reviewing the benefits of herbal cannabis preparations for the treatment of chronic pain in adults and the harms of cannabis use in Chronic pain and adult populations in general. View study
The effects of delta9-tetrahydrocannabinol and cannabidiol on the metabolism of gonadal steroids in the rat (1978)

This research aimed to study the effects of 9-tetrahydrocannabinol (THC) and cannabidiol (CBD) on the hydroxylation of estradiol and testosterone in rat liver microsomes View study
The effects of Positive Youth Development interventions on substance use, violence and inequalities: systematic review of theories of change, processes and outcomes (2016)

The positive development of youth that takes place outside of school aims to enable young people to develop positive assets, such as relationships and trust, instead of just addressing risk, violence, alcohol and illicit drugs. View study
The Emerging Role of the Endocannabinoid System in Endocrine Regulation and Energy Balance (2008)

During these last years, the endocannabinoid system has emerged as a highly relevant issue in the scientific community. The cannabinoid receptors, called CB1 receptor and CB2 receptor, first discovered as molecular targets of the psychotropic component of the Cannabis sativa plant, participate in the physiological modulation of many central and peripheral functions. This research aimed to study the emerging role of the endocannabinoid system in endocrine regulation and energy balance View study
The endocannabinoid system and cancer: therapeutic implication (2011)

The endocannabinoid system is implicated in a variety of physiological and pathological conditions. This research focused on the study of how endocannabinoid activation affects breast, prostate and bone cancers in the in vitro and in vivo systems. View study
The endocannabinoid system and migraine ()

The recently discovered endocannabinoid system (ECS), which includes endocannabinoids and the proteins that metabolize and bind them, has been implicated in multiple regulatory functions in both health and disease. Several studies have suggested that (ECS) is involved centrally and peripherally in the processing of pain signals. The present review will aim to describe experimental and clinical data that, intriguingly, demonstrate the link between endocannabinoids and migraine, a neurovascular disorder characterized by recurrent episodes and caused by the abnormal use of sensory information due to peripheral sensitization and / or central. View study
The Endocannabinoid System and Plant-Derived Cannabinoids in Diabetes and Diabetic Complications (2012)

It has been previously shown that the modulation of the endocannabinoid system can have an enormous therapeutic potential in a wide range of diseases. This study focuses on the role of the endocannabinoid system in primary diabetes and its effects on various diabetic complications. View study
The Endocannabinoid System as an Emerging Target of Pharmacotherapy (2006)

Marijuana, or cannabis, is the most widely used illicit drug in Western societies and also the one with the longest recorded history of human use. However, the ability of extracts from the hemp plant (Cannabis sativa) to cause a variety of medicinal effects unrelated to its psychoactive properties had been recognized as early as the third millennium BC. This study shows a global view about the current state of knowledge of the endocannabinoid system as an objective of pharmacotherapy. View study
The endocannabinoid system drives neural progenitor proliferation (2005)

The discovery of multipotent neural progenitor (NP) cells has given great support to the existence of neurogenesis in the adult brain. Endocannabinoids, derived from marijuana, act as neuromodulators through CB1 presynaptic receptors and also control the death and survival of neural cells. In this study we show that progenitor cells express a functional endocannabinoid system that actively regulates cell proliferation both in vitro and in vivo. Specifically, the (NP) produce endocannabinoids and express the CB1 receptor and the endocannabinoid inactivating fatty acid hydrolase enzyme (FAAH). View study
The endocannabinoid system in cancer- Potential therapeutic target? (2008)

The present study has as objective the revision of several means by which the endocannabinoid system can be attacked in cancer and the current knowledge considering the regulation of the endocannabinoid system in the malignancy. View study